| Pair Name | Betulinic Acid, Gemcitabine | ||
| Phytochemical Name | Betulinic Acid (PubChem CID: 64971 ) | ||
| Anticancer drug Name | Gemcitabine (PubChem CID: 60750 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Betulinic Acid, Gemcitabine | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | CHEK1 | hsa1111 |
| Down-regulation | Phosphorylation | RPA2 | KEGG ID N.A. | |
| In Vitro Model | BxPC-3 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0186 |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 | |
| HEK293T | Healthy | Homo sapiens (Human) | CVCL_0063 | |
| In Vivo Model | To establish tumor xenograft, exponentially growing mCherry-BxPC-3 cells were mixed at a 2:1 ratio with Matrigel (Becton Dickinson, Bedford, MA) and a 200 μL suspension containing 5×10⁶ cells was subcutaneously inoculated into the right flank of each mouse. | |||
| Result | These data provide evidence that betulinic acid is a potential candidate for chemosensitization as a naturally occurring Chk1 inhibitor and warrants further preclinical evaluation. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation. J Ethnopharmacol. 2023 Jun 12;309:116295. doi: 10.1016/j.jep.2023.116295. | Click |
